<p>Mammalian Co-A dehydrogenases (<db_xref db="EC" dbkey="1.3.99.3"/>) are enzymes that catalyse the first step in each cycle of beta-oxidation in mitochondion. Acyl-CoA dehydrogenases [<cite idref="PUB00001328"/>, <cite idref="PUB00002511"/>, <cite idref="PUB00002861"/>] catalyze the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD. Reoxidation of the flavin involves transfer of electrons to ETF (electron transfering flavoprotein) [<cite idref="PUB00007933"/>]. These enzymes are homodimers containing one molecule of FAD.</p> Acyl-CoA dehydrogenase, conserved site